A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

• Main Authors: Michael Buchert (Author), Franziska Rohde (Author), Moritz Eissmann (Author), Niall Tebbutt (Author), Ben Williams (Author), Chin Wee Tan (Author), Alexander Owen (Author), Yumiko Hirokawa (Author), Alexandra Gnann (Author), Gertraud Orend (Author), Gayle Orner (Author), Rod H. Dashwood (Author), Joan K. Heath (Author), Matthias Ernst (Author), Klaus-Peter Janssen (Author)
• Format: Book
• Published: The Company of Biologists, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors...