A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

• Главные авторы: Michael Buchert (Автор), Franziska Rohde (Автор), Moritz Eissmann (Автор), Niall Tebbutt (Автор), Ben Williams (Автор), Chin Wee Tan (Автор), Alexander Owen (Автор), Yumiko Hirokawa (Автор), Alexandra Gnann (Автор), Gertraud Orend (Автор), Gayle Orner (Автор), Rod H. Dashwood (Автор), Joan K. Heath (Автор), Matthias Ernst (Автор), Klaus-Peter Janssen (Автор)
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• Опубликовано: The Company of Biologists, 2015-11-01T00:00:00Z.
• Предметы: article
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Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors...