A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner

• Autori principali: Zi-Hui Wang (Autore), Jin Li (Autore), Qian Liu (Autore), Jian-Chang Qian (Autore), Qing-Qing Li (Autore), Qing-Yu Wang (Autore), Lv-Tao Zeng (Autore), Si-Jia Li (Autore), Xin Gao (Autore), Jia-Xin Pan (Autore), Xu-Fan Gao (Autore), Kun Wu (Autore), Guo-Xin Hu (Autore), Tomoo Iwakuma (Autore), Jian-Ping Cai (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2024-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM), has emerged as a formidable obstacle, underscoring the imperative to identify alternative therapeutic strategies to improve patient outcomes. In this study, we comprehensively evaluated a novel agent, O6-m...