A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner

• Main Authors: Zi-Hui Wang (Author), Jin Li (Author), Qian Liu (Author), Jian-Chang Qian (Author), Qing-Qing Li (Author), Qing-Yu Wang (Author), Lv-Tao Zeng (Author), Si-Jia Li (Author), Xin Gao (Author), Jia-Xin Pan (Author), Xu-Fan Gao (Author), Kun Wu (Author), Guo-Xin Hu (Author), Tomoo Iwakuma (Author), Jian-Ping Cai (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM), has emerged as a formidable obstacle, underscoring the imperative to identify alternative therapeutic strategies to improve patient outcomes. In this study, we comprehensively evaluated a novel agent, O6-m...