Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases

• Main Authors: Julia Sellin (Author), Heike Schulze (Author), Marie Paradis (Author), Dominic Gosejacob (Author), Cyrus Papan (Author), Andrej Shevchenko (Author), Olympia Ekaterina Psathaki (Author), Achim Paululat (Author), Melanie Thielisch (Author), Konrad Sandhoff (Author), Michael Hoch (Author)
• Format: Book
• Published: The Company of Biologists, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery. While some LSDs can be efficiently treated by e...