Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases

• Главные авторы: Julia Sellin (Автор), Heike Schulze (Автор), Marie Paradis (Автор), Dominic Gosejacob (Автор), Cyrus Papan (Автор), Andrej Shevchenko (Автор), Olympia Ekaterina Psathaki (Автор), Achim Paululat (Автор), Melanie Thielisch (Автор), Konrad Sandhoff (Автор), Michael Hoch (Автор)
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• Опубликовано: The Company of Biologists, 2017-06-01T00:00:00Z.
• Предметы: article
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Sphingolipidoses are inherited diseases belonging to the class of lysosomal storage diseases (LSDs), which are characterized by the accumulation of indigestible material in the lysosome caused by specific defects in the lysosomal degradation machinery. While some LSDs can be efficiently treated by e...