Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides

• Autori principali: Tingting Lin (Autore), Ergang Liu (Autore), Huining He (Autore), Meong Cheol Shin (Autore), Cheol Moon (Autore), Victor C. Yang (Autore), Yongzhuo Huang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2016-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Brain delivery of macromolecular therapeutics (e.g., proteins) remains an unsolved problem because of the formidable blood-brain barrier (BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain deli...