Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency

• Asıl Yazarlar: Mianqiao Chen (Yazar), Xiong Tian (Yazar), Liqun Xu (Yazar), Ruolan Wu (Yazar), Haoming He (Yazar), Haibao Zhu (Yazar), Wencan Xu (Yazar), Chi-ju Wei (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible CreER-loxP system with superior labeling char...