Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency

• Váldodahkkit: Mianqiao Chen (Dahkki), Xiong Tian (Dahkki), Liqun Xu (Dahkki), Ruolan Wu (Dahkki), Haoming He (Dahkki), Haibao Zhu (Dahkki), Wencan Xu (Dahkki), Chi-ju Wei (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2022-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible CreER-loxP system with superior labeling char...