Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency

• Päätekijät: Mianqiao Chen (Tekijä), Xiong Tian (Tekijä), Liqun Xu (Tekijä), Ruolan Wu (Tekijä), Haoming He (Tekijä), Haibao Zhu (Tekijä), Wencan Xu (Tekijä), Chi-ju Wei (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2022-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible CreER-loxP system with superior labeling char...