Overcoming Resistance to Immune Checkpoint Inhibitor Therapy Using Calreticulin-Inducing Nanoparticle

• Main Authors: Sri Vidhya Chandrasekar (Author), Akansha Singh (Author), Ashish Ranjan (Author)
• Format: Bog
• Udgivet: MDPI AG, 2023-06-01T00:00:00Z.
• Fag: article
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Nanoparticles (NPs) have the ability to transform poorly immunogenic tumors into activated 'hot' targets. In this study, we investigated the potential of a liposome-based nanoparticle (CRT-NP) expressing calreticulin as an in-situ vaccine to restore sensitivity to anti-CTLA4 immune checkpo...