Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• المؤلفون الرئيسيون: Rocío Gambaro (مؤلف), Ignacio Rivero Berti (مؤلف), María José Limeres (مؤلف), Cristián Huck-Iriart (مؤلف), Malin Svensson (مؤلف), Silvia Fraude (مؤلف), Leah Pretsch (مؤلف), Shutian Si (مؤلف), Ingo Lieberwirth (مؤلف), Stephan Gehring (مؤلف), Maximiliano Cacicedo (مؤلف), Germán Abel Islan (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...