Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• প্রধান লেখক: Rocío Gambaro (লেখক), Ignacio Rivero Berti (লেখক), María José Limeres (লেখক), Cristián Huck-Iriart (লেখক), Malin Svensson (লেখক), Silvia Fraude (লেখক), Leah Pretsch (লেখক), Shutian Si (লেখক), Ingo Lieberwirth (লেখক), Stephan Gehring (লেখক), Maximiliano Cacicedo (লেখক), Germán Abel Islan (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...