Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Prif Awduron: Rocío Gambaro (Awdur), Ignacio Rivero Berti (Awdur), María José Limeres (Awdur), Cristián Huck-Iriart (Awdur), Malin Svensson (Awdur), Silvia Fraude (Awdur), Leah Pretsch (Awdur), Shutian Si (Awdur), Ingo Lieberwirth (Awdur), Stephan Gehring (Awdur), Maximiliano Cacicedo (Awdur), Germán Abel Islan (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2024-06-01T00:00:00Z.
• Pynciau: article
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Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...