Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Päätekijät: Rocío Gambaro (Tekijä), Ignacio Rivero Berti (Tekijä), María José Limeres (Tekijä), Cristián Huck-Iriart (Tekijä), Malin Svensson (Tekijä), Silvia Fraude (Tekijä), Leah Pretsch (Tekijä), Shutian Si (Tekijä), Ingo Lieberwirth (Tekijä), Stephan Gehring (Tekijä), Maximiliano Cacicedo (Tekijä), Germán Abel Islan (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...