Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Príomhchruthaitheoirí: Rocío Gambaro (Údar), Ignacio Rivero Berti (Údar), María José Limeres (Údar), Cristián Huck-Iriart (Údar), Malin Svensson (Údar), Silvia Fraude (Údar), Leah Pretsch (Údar), Shutian Si (Údar), Ingo Lieberwirth (Údar), Stephan Gehring (Údar), Maximiliano Cacicedo (Údar), Germán Abel Islan (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2024-06-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...