Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• 主要な著者: Rocío Gambaro (著者), Ignacio Rivero Berti (著者), María José Limeres (著者), Cristián Huck-Iriart (著者), Malin Svensson (著者), Silvia Fraude (著者), Leah Pretsch (著者), Shutian Si (著者), Ingo Lieberwirth (著者), Stephan Gehring (著者), Maximiliano Cacicedo (著者), Germán Abel Islan (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...