Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Główni autorzy: Rocío Gambaro (Autor), Ignacio Rivero Berti (Autor), María José Limeres (Autor), Cristián Huck-Iriart (Autor), Malin Svensson (Autor), Silvia Fraude (Autor), Leah Pretsch (Autor), Shutian Si (Autor), Ingo Lieberwirth (Autor), Stephan Gehring (Autor), Maximiliano Cacicedo (Autor), Germán Abel Islan (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...