Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Автори: Rocío Gambaro (Автор), Ignacio Rivero Berti (Автор), María José Limeres (Автор), Cristián Huck-Iriart (Автор), Malin Svensson (Автор), Silvia Fraude (Автор), Leah Pretsch (Автор), Shutian Si (Автор), Ingo Lieberwirth (Автор), Stephan Gehring (Автор), Maximiliano Cacicedo (Автор), Germán Abel Islan (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2024-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...