A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

• Main Authors: Fox Sarah (Author), Gasco Alberto (Author), Fruttero Roberta (Author), Cena Clara (Author), Lazzarato Loretta (Author), Sheldrake Tara A (Author), Marcarino Paolo (Author), Turnbull Catriona M (Author), Megson Ian L (Author), Rossi Adriano G (Author)
• Format: Book
• Published: BMC, 2008-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The cytoprotective nature of nitric oxide (NO) led to development of NO-aspirins in the hope of overcoming the gastric side-effects of aspirin. However, the NO moiety gives these hybrids potential for actions further to their aspirin...