Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

• मुख्य लेखकों: Riccardo Cavalieri (लेखक), Marlou Klein Hazebroek (लेखक), Camila A. Cotrim (लेखक), Yang Lee (लेखक), Edmund R.S. Kunji (लेखक), Martin Jastroch (लेखक), Susanne Keipert (लेखक), Paul G. Crichton (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids generated from lip...