Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

• Main Authors: Riccardo Cavalieri (Author), Marlou Klein Hazebroek (Author), Camila A. Cotrim (Author), Yang Lee (Author), Edmund R.S. Kunji (Author), Martin Jastroch (Author), Susanne Keipert (Author), Paul G. Crichton (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids generated from lip...