Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors

• Main Authors: Eric Hatterer (Author), Xavier Chauchet (Author), Françoise Richard (Author), Leticia Barba (Author), Valéry Moine (Author), Laurence Chatel (Author), Lucile Broyer (Author), Guillemette Pontini (Author), Tereza Bautzova (Author), Flora Juan (Author), Sebastien Calloud (Author), Nicolas Bosson (Author), Maud Charreton (Author), Krzysztof Masternak (Author), Vanessa Buatois (Author), Limin Shang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian cancers. While several MSLN-targeting therapeutic approaches are in development, only limited efficacy has been achieved in patients. A potentia...