Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors

• প্রধান লেখক: Eric Hatterer (লেখক), Xavier Chauchet (লেখক), Françoise Richard (লেখক), Leticia Barba (লেখক), Valéry Moine (লেখক), Laurence Chatel (লেখক), Lucile Broyer (লেখক), Guillemette Pontini (লেখক), Tereza Bautzova (লেখক), Flora Juan (লেখক), Sebastien Calloud (লেখক), Nicolas Bosson (লেখক), Maud Charreton (লেখক), Krzysztof Masternak (লেখক), Vanessa Buatois (লেখক), Limin Shang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian cancers. While several MSLN-targeting therapeutic approaches are in development, only limited efficacy has been achieved in patients. A potentia...