<i>In Vitro</i> and <i>In Vivo</i> Inhibition of MATE1 by Tyrosine Kinase Inhibitors

• Main Authors: Muhammad Erfan Uddin (Author), Zahra Talebi (Author), Sijie Chen (Author), Yan Jin (Author), Alice A. Gibson (Author), Anne M. Noonan (Author), Xiaolin Cheng (Author), Shuiying Hu (Author), Alex Sparreboom (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The membrane transport of many cationic prescription drugs depends on facilitated transport by organic cation transporters of which several members, including OCT2 (<i>SLC22A2</i>), are sensitive to inhibition by select tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs may dif...