<i>In Vitro</i> and <i>In Vivo</i> Inhibition of MATE1 by Tyrosine Kinase Inhibitors

• Hoofdauteurs: Muhammad Erfan Uddin (Auteur), Zahra Talebi (Auteur), Sijie Chen (Auteur), Yan Jin (Auteur), Alice A. Gibson (Auteur), Anne M. Noonan (Auteur), Xiaolin Cheng (Auteur), Shuiying Hu (Auteur), Alex Sparreboom (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The membrane transport of many cationic prescription drugs depends on facilitated transport by organic cation transporters of which several members, including OCT2 (<i>SLC22A2</i>), are sensitive to inhibition by select tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs may dif...