Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients

• Main Authors: David Heftrig (Author), Ramona Sturm (Author), Elsie Oppermann (Author), Kerstin Kontradowitz (Author), Katrin Jurida (Author), Lukas Schimunek (Author), Mathias Woschek (Author), Ingo Marzi (Author), Borna Relja (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective. Trauma patients (TP) frequently develop an imbalanced immune response that often causes infectious postinjury complications. Monocytes show a diminished capability of both producing proinflammatory cytokines and antigen presentation after trauma. TLR2, TLR4, and TLR9 recognize pathogens a...