Renal function as a predicting model for plasma methotrexate concentration after high-dose methotrexate chemotherapy in pediatric malignancy

• Главные авторы: Kaveh Jaseb (Автор), Ehsan Ghaedi (Автор), Mohadeseh Shahin (Автор), Majid Mirmohamadkhani (Автор), Parisa Javadian (Автор), Sabahat Haghi (Автор)
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• Опубликовано: Society of Diabetic Nephropathy Prevention, 2018-05-01T00:00:00Z.
• Предметы: article
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Introduction: Methotrexate (MTX) is the most generally administered antimetabolite in pediatric cancers. Renal excretion is the major route of elimination of MTX. However, renal toxicity and delayed MTX elimination is a particular concern and direct serum MTX concentration is a gold standard for ren...