Renal function as a predicting model for plasma methotrexate concentration after high-dose methotrexate chemotherapy in pediatric malignancy

• Main Authors: Kaveh Jaseb (Author), Ehsan Ghaedi (Author), Mohadeseh Shahin (Author), Majid Mirmohamadkhani (Author), Parisa Javadian (Author), Sabahat Haghi (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Methotrexate (MTX) is the most generally administered antimetabolite in pediatric cancers. Renal excretion is the major route of elimination of MTX. However, renal toxicity and delayed MTX elimination is a particular concern and direct serum MTX concentration is a gold standard for ren...