Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis

• Main Authors: Yu-Lei Gao (Author), Yan-Fen Chai (Author), An-Long Qi (Author), Ying Yao (Author), Yan-Cun Liu (Author), Ning Dong (Author), Li-Jun Wang (Author), Yong-Ming Yao (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regulatory T cells (Tregs) appear to be involved in sepsis-induced immune dysfunction; neuropilin-1 (Nrp-1) was identified as a surface marker for CD4+CD25+Tregs. In the current study, we investigated the negative immunoregulation of Nrp-1highCD4+CD25+Tregs and the potential therapeutic value of Nrp...