Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH

• Main Authors: Leandro F. Pippa (Author), Valvanera Vozmediano (Author), Lieke Mitrov‐Winkelmolen (Author), Daan Touw (Author), Amira Soliman (Author), Rodrigo Cristofoletti (Author), Wilson Salgado Junior (Author), Natalia Valadares de Moraes (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study employed physiologically‐based pharmacokinetic-pharmacodynamics (PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on the pharmacokinetics and intragastric pH following omeprazole treatment. The simulated plasma concentrations closely matched the obser...