Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH

• मुख्य लेखकों: Leandro F. Pippa (लेखक), Valvanera Vozmediano (लेखक), Lieke Mitrov‐Winkelmolen (लेखक), Daan Touw (लेखक), Amira Soliman (लेखक), Rodrigo Cristofoletti (लेखक), Wilson Salgado Junior (लेखक), Natalia Valadares de Moraes (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract This study employed physiologically‐based pharmacokinetic-pharmacodynamics (PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on the pharmacokinetics and intragastric pH following omeprazole treatment. The simulated plasma concentrations closely matched the obser...