Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice

• প্রধান লেখক: Javier Reig-López (লেখক), María del Mar Maldonado (লেখক), Matilde Merino-Sanjuan (লেখক), Ailed M. Cruz-Collazo (লেখক), Jean F. Ruiz-Calderón (লেখক), Victor Mangas-Sanjuán (লেখক), Suranganie Dharmawardhane (লেখক), Jorge Duconge (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2020-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based p...