Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice

• Main Authors: Javier Reig-López (Author), María del Mar Maldonado (Author), Matilde Merino-Sanjuan (Author), Ailed M. Cruz-Collazo (Author), Jean F. Ruiz-Calderón (Author), Victor Mangas-Sanjuán (Author), Suranganie Dharmawardhane (Author), Jorge Duconge (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based p...