High frequency of the 3R/3R polymorphism in the thymidylate synthase enhancer region in Indonesian childhood acute lymphoblastic leukemia

Background Deoxyuridylate monophosphate (dTMP) is neces- sary for DNA synthesis and thymidylate synthase (TS) is an im- portant target of cancer chemotherapy. Ethnic variations of the polymorphic tandem repeat sequence in the enhancer region of the TS promoter has previously been described to influe...

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Main Authors: IDG Ugrasena (Author), Sutaryo Sutaryo (Author), Edy Supriadi (Author), Laura Vroling (Author), Jacqueline Cloos (Author), Jan Hendrik Hooijberg (Author), AJP Veerman (Author)
Formato: Livro
Publicado em: Indonesian Pediatric Society Publishing House, 2016-10-01T00:00:00Z.
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