High frequency of the 3R/3R polymorphism in the thymidylate synthase enhancer region in Indonesian childhood acute lymphoblastic leukemia

• Main Authors: IDG Ugrasena (Author), Sutaryo Sutaryo (Author), Edy Supriadi (Author), Laura Vroling (Author), Jacqueline Cloos (Author), Jan Hendrik Hooijberg (Author), AJP Veerman (Author)
• Format: Book
• Published: Indonesian Pediatric Society Publishing House, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Deoxyuridylate monophosphate (dTMP) is neces- sary for DNA synthesis and thymidylate synthase (TS) is an im- portant target of cancer chemotherapy. Ethnic variations of the polymorphic tandem repeat sequence in the enhancer region of the TS promoter has previously been described to influe...