High frequency of the 3R/3R polymorphism in the thymidylate synthase enhancer region in Indonesian childhood acute lymphoblastic leukemia

• Asıl Yazarlar: IDG Ugrasena (Yazar), Sutaryo Sutaryo (Yazar), Edy Supriadi (Yazar), Laura Vroling (Yazar), Jacqueline Cloos (Yazar), Jan Hendrik Hooijberg (Yazar), AJP Veerman (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Indonesian Pediatric Society Publishing House, 2016-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background Deoxyuridylate monophosphate (dTMP) is neces- sary for DNA synthesis and thymidylate synthase (TS) is an im- portant target of cancer chemotherapy. Ethnic variations of the polymorphic tandem repeat sequence in the enhancer region of the TS promoter has previously been described to influe...