Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

• Main Authors: Benjamin E. Low (Author), Gregory J. Christianson (Author), Emily Lowell (Author), Wenning Qin (Author), Michael V. Wiles (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...