Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

• Asıl Yazarlar: Benjamin E. Low (Yazar), Gregory J. Christianson (Yazar), Emily Lowell (Yazar), Wenning Qin (Yazar), Michael V. Wiles (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...