Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

• Hoofdauteurs: Benjamin E. Low (Auteur), Gregory J. Christianson (Auteur), Emily Lowell (Auteur), Wenning Qin (Auteur), Michael V. Wiles (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...