Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

• Main Authors: Huang-Ju Tu (Author), Min-Wu Chao (Author), Cheng-Chung Lee (Author), Chao-Shiang Peng (Author), Yi-Wen Wu (Author), Tony Eight Lin (Author), Yu-Wei Chang (Author), Shih-Chung Yen (Author), Kai-Cheng Hsu (Author), Shiow-Lin Pan (Author), Wei-Chun HuangFu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development of DYRK1A inhibitors has significantly adva...