Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

• Hoofdauteurs: Huang-Ju Tu (Auteur), Min-Wu Chao (Auteur), Cheng-Chung Lee (Auteur), Chao-Shiang Peng (Auteur), Yi-Wen Wu (Auteur), Tony Eight Lin (Auteur), Yu-Wei Chang (Auteur), Shih-Chung Yen (Auteur), Kai-Cheng Hsu (Auteur), Shiow-Lin Pan (Auteur), Wei-Chun HuangFu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development of DYRK1A inhibitors has significantly adva...