Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

• Váldodahkkit: Huang-Ju Tu (Dahkki), Min-Wu Chao (Dahkki), Cheng-Chung Lee (Dahkki), Chao-Shiang Peng (Dahkki), Yi-Wen Wu (Dahkki), Tony Eight Lin (Dahkki), Yu-Wei Chang (Dahkki), Shih-Chung Yen (Dahkki), Kai-Cheng Hsu (Dahkki), Shiow-Lin Pan (Dahkki), Wei-Chun HuangFu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development of DYRK1A inhibitors has significantly adva...