Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

• Hauptverfasser: Huang-Ju Tu (Verfasst von), Min-Wu Chao (Verfasst von), Cheng-Chung Lee (Verfasst von), Chao-Shiang Peng (Verfasst von), Yi-Wen Wu (Verfasst von), Tony Eight Lin (Verfasst von), Yu-Wei Chang (Verfasst von), Shih-Chung Yen (Verfasst von), Kai-Cheng Hsu (Verfasst von), Shiow-Lin Pan (Verfasst von), Wei-Chun HuangFu (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development of DYRK1A inhibitors has significantly adva...