Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

• Päätekijät: Huang-Ju Tu (Tekijä), Min-Wu Chao (Tekijä), Cheng-Chung Lee (Tekijä), Chao-Shiang Peng (Tekijä), Yi-Wen Wu (Tekijä), Tony Eight Lin (Tekijä), Yu-Wei Chang (Tekijä), Shih-Chung Yen (Tekijä), Kai-Cheng Hsu (Tekijä), Shiow-Lin Pan (Tekijä), Wei-Chun HuangFu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development of DYRK1A inhibitors has significantly adva...