Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis

• Main Authors: Majid Ghareghani (Author), Linda Scavo (Author), Yahya Jand (Author), Naser Farhadi (Author), Hossein Sadeghi (Author), Amir Ghanbari (Author), Stefania Mondello (Author), Damien Arnoult (Author), Sajjad Gharaghani (Author), Kazem Zibara (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes. In this study, we evaluated the effect of melatonin, at...