Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis

• Hoofdauteurs: Majid Ghareghani (Auteur), Linda Scavo (Auteur), Yahya Jand (Auteur), Naser Farhadi (Auteur), Hossein Sadeghi (Auteur), Amir Ghanbari (Auteur), Stefania Mondello (Auteur), Damien Arnoult (Auteur), Sajjad Gharaghani (Auteur), Kazem Zibara (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes. In this study, we evaluated the effect of melatonin, at...