Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

• Principais autores: Mohammad Abdel-Halim (Autor), Dalia S. El-Gamil (Autor), Mennatallah A. Hammam (Autor), Mohamed El-Shazly (Autor), Yi-Hsuan Wang (Autor), Po-Hsiung Kung (Autor), Yu-Cheng Chen (Autor), Michal Korinek (Autor), Ashraf H. Abadi (Autor), Matthias Engel (Autor), Tsong-Long Hwang (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds...