Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

• Main Authors: Mohammad Abdel-Halim (Author), Dalia S. El-Gamil (Author), Mennatallah A. Hammam (Author), Mohamed El-Shazly (Author), Yi-Hsuan Wang (Author), Po-Hsiung Kung (Author), Yu-Cheng Chen (Author), Michal Korinek (Author), Ashraf H. Abadi (Author), Matthias Engel (Author), Tsong-Long Hwang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds...