Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility

• 主要な著者: Jalisa H. Ferguson (著者), Zeus De Los Santos (著者), Saroja N. Devi (著者), Stefan Kaluz (著者), Erwin G. Van Meir (著者), Sarah K. Zingales (著者), Binghe Wang (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells...