Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility

• Main Authors: Jalisa H. Ferguson (Author), Zeus De Los Santos (Author), Saroja N. Devi (Author), Stefan Kaluz (Author), Erwin G. Van Meir (Author), Sarah K. Zingales (Author), Binghe Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells...