Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility

• Главные авторы: Jalisa H. Ferguson (Автор), Zeus De Los Santos (Автор), Saroja N. Devi (Автор), Stefan Kaluz (Автор), Erwin G. Van Meir (Автор), Sarah K. Zingales (Автор), Binghe Wang (Автор)
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• Опубликовано: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Предметы: article
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While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells...