Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells

• Главные авторы: Shannon R. Barwick (Автор), Mevish S. Siddiq (Автор), Jing Wang (Автор), Haiyan Xiao (Автор), Brendan Marshall (Автор), Elizabeth Perry (Автор), Sylvia B. Smith (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2021-06-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Sigma 1 receptor (Sig1R), a modulator of cell survival, has emerged as a novel target for retinal degenerative disease. Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a severe retinopathy model. The rescue is accompani...