Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells

• Główni autorzy: Shannon R. Barwick (Autor), Mevish S. Siddiq (Autor), Jing Wang (Autor), Haiyan Xiao (Autor), Brendan Marshall (Autor), Elizabeth Perry (Autor), Sylvia B. Smith (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Sigma 1 receptor (Sig1R), a modulator of cell survival, has emerged as a novel target for retinal degenerative disease. Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a severe retinopathy model. The rescue is accompani...