In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug

• Main Authors: Changzhi Shi (Author), Jelisaveta Ignjatović (Author), Tingting Liu (Author), Meihua Han (Author), Dongmei Cun (Author), Jelena Đuriš (Author), Mingshi Yang (Author), Sandra Cvijić (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) commercially available micronized BUD mixed with lactose (BUD-PT), (ii) BUD nanoc...