Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma

• Main Authors: Ye Li (Author), Yuncang Yuan (Author), Fan Zhang (Author), Aizhen Guo (Author), Fuao Cao (Author), Mengmeng Song (Author), Yating Fu (Author), Xiaowen Xu (Author), Hao Shen (Author), Shangyong Zheng (Author), Yamin Pan (Author), Wenjun Chang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment. Although the ERK signaling variation after SHP2 inhibition has been well inves...