Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma

• Главные авторы: Ye Li (Автор), Yuncang Yuan (Автор), Fan Zhang (Автор), Aizhen Guo (Автор), Fuao Cao (Автор), Mengmeng Song (Автор), Yating Fu (Автор), Xiaowen Xu (Автор), Hao Shen (Автор), Shangyong Zheng (Автор), Yamin Pan (Автор), Wenjun Chang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment. Although the ERK signaling variation after SHP2 inhibition has been well inves...