Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

• मुख्य लेखकों: Yun-Kyoung Lee (लेखक), Wen Du (लेखक), Yaohui Nie (लेखक), Bryan Diaz (लेखक), Nishat Sultana (लेखक), Takumi Kitamoto (लेखक), Rudolph L. Leibel (लेखक), Domenico Accili (लेखक), Sandro Belvedere (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of FOXO1. We have previously shown that th...