Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

• Main Authors: Yun-Kyoung Lee (Author), Wen Du (Author), Yaohui Nie (Author), Bryan Diaz (Author), Nishat Sultana (Author), Takumi Kitamoto (Author), Rudolph L. Leibel (Author), Domenico Accili (Author), Sandro Belvedere (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of FOXO1. We have previously shown that th...