Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

• Hoofdauteurs: Yun-Kyoung Lee (Auteur), Wen Du (Auteur), Yaohui Nie (Auteur), Bryan Diaz (Auteur), Nishat Sultana (Auteur), Takumi Kitamoto (Auteur), Rudolph L. Leibel (Auteur), Domenico Accili (Auteur), Sandro Belvedere (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of FOXO1. We have previously shown that th...