Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

• Váldodahkkit: Yun-Kyoung Lee (Dahkki), Wen Du (Dahkki), Yaohui Nie (Dahkki), Bryan Diaz (Dahkki), Nishat Sultana (Dahkki), Takumi Kitamoto (Dahkki), Rudolph L. Leibel (Dahkki), Domenico Accili (Dahkki), Sandro Belvedere (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of FOXO1. We have previously shown that th...