Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress

• Autori principali: Panshuang Qiao (Autore), Yi Sun (Autore), Yiming Wang (Autore), Simei Lin (Autore), Yongpan An (Autore), Liang Wang (Autore), Jihan Liu (Autore), Yajun Huang (Autore), Baoxue Yang (Autore), Hong Zhou (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Hyperuricemia (HUA)-induced oxidative stress is a crucial contributor to hyperuricemic nephropathy (HN), but the molecular mechanisms underlying the disturbed redox homeostasis in kidneys remain elusive. Using RNA sequencing, together with biochemical analyses, we found that nuclear factor erythroid...